Special Design For Pharmaceutical Intermediates - Highly toxic liquid superior product propargyl alcoho – Haiyuan

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Special Design For Pharmaceutical Intermediates - Highly toxic liquid superior product propargyl alcoho – Haiyuan Detail:

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Liquid with volatile and pungent odor. It is miscible with water, ethanol, aldehydes, benzene, pyridine, chloroform and other organic solvents, partially soluble in carbon tetrachloride, but insoluble in aliphatic hydrocarbons. It is easy to turn yellow when it is placed for a long time, especially when it meets light. It can form azeotrope with water, the azeotropic point is 97 ℃, and the content of propargyl alcohol is 21 2%。 It can form azeotrope with benzene, the azeotropic point is 73 ℃, and the content of propargyl alcohol is 13.8%. Its vapor and air form an explosive mixture, which can cause combustion and explosion in case of open fire and high heat. It can react strongly with oxidants. In case of high heat, polymerization reaction may occur and a large number of exothermic phenomena may occur, resulting in container cracking and explosion accidents.

Melting point	-53 °C
Boiling point	114-115 ° C (lit.)
Density	0.963g/mlat25 °C (lit.)
Vapor density	1.93 (vsair)
Vapor pressure	11.6mmhg (20 °C)
Refractive index	n20/d1.432 (lit.)
Flash point	97 °f
AR,GR,GCS,CP
Appearance	colorless to yellowish liquid
Purity	≥ 99.0% (GC)
Water	≤ 0.1%
Specific gravity (20/20 ° C)	0.9620 ～ 0.99650
Refractive index refractiveindexn20/d	1.4310 ～ 1.4340

Propargyl alcohol is widely used in hospitals (sulfonamides, fosfomycin sodium, etc.) and the production of pesticides (propargyl mite). It can be made into corrosion inhibitors for drill pipes and oil pipes in the petroleum industry. It can be used as an additive in the steel industry to prevent hydrogen embrittlement of steel. It can be made into brighteners in the electroplating industry.

Propargyl alcohol is a highly classified chemical product with acute toxicity: ld5020mg/kg (oral administration to rats); 16mg/kg (rabbit percutaneous); Lc502000mg/m32 hours (inhalation in rats); Mice inhaled 2mg/l × 2 hours, fatal.

Subacute and chronic toxicity: rats inhaled 80ppm × 7 hours / day × 5 days / week × On the 89th day, the liver and kidney swelled and the cells degenerated.

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Cas No 624-65-7

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